STUDY OF THE ANTITUMOR EFFECT OF UKRAIN: THE ROLE OF MACROPHAGE SECRETION OF α-1-PROTEINASE INHIBITOR
KOROLENKO T.A.1, KALEDIN V.I.2, SVECHNIKOVA I.G.1, LI X.V.1, STASHKO J.F.1, ILNITSKAYA S.I.2, NIKOLIN V.P.2
1) Institute of Physiology, Siberian Branch of Russian
Academy of Medical Sciences, Novosibirsk, Russia.
2) Institute of Cytology and Genetics, Siberian Branch of Academy of Sciences, Novosibirsk, Russia.
Address for correspondence: T.A. Korolenko, Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Timakov Str. 4, Novosibirsk, 630117, Russia.
Summary: The positive antitumor effect of Ukrain was shown following i.m. injection o f a mixture of this drug with Krebs-2 carcinoma cells to CBA mice. The protective effect was suggested to be a result of the influx of macrophages into the site of Ukrain injection. In contrast, contralateral administration of Ukrain had a negative effect, confirming our hypothesis that Ukrain attracts cytolytic macrophages. In the murine HA-1 hepatoma model treated by single or repeated Ukrain injections, a moderate positive effect of Ukrain was related to increased macrophage α-1-proteinase inhibitor (PI) secretion. The role of tumor cells and macrophages in the secretion of PI (the main inhibitor of serine proteinases) during tumor development is discussed.