INFLUENCE OF UKRAIN ON HUMAN XENOGRAFTS IN VITRO

NOWICKY J.W.¹*, HIESMAYR W.¹, NOWICKY W.¹, LIEPINS A.²

1) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.
2) Faculty of Medicine, Memorial University, St. John's, Newfoundland, A1B 3V6, Canada.

* Author to whom correspondence should be addressed.
** Austrian Patent No. 354644.

KeyWords: colorectal, gastric, large cell lung, breast, ovarian, cancers and malignant melanoma.

Summary: Tumour cells were taken from human tumour xenografts (HTX) and serially transplanted into nude mice. These cells were used in a colony-forming assay in vitro. Tumour cells were incubated continuously for at least one week with several concentrations of the drug Ukrain. This was done with six different types¹ and the colony formation was scored for each tumour. The drug effects were reported as percent T/C (Test/Control) for the numbers of colonies formed. Activity is considered to be present at T/C<30%. A clear dose-response effect was found for Ukrain.