EFFECT OF SINGLE AND THREE MONTHS TREATMENT WITH UKRAIN ON AMINOTRANSFERASES (ALT AND AST) AND ON THE SERUM PROTEIN LEVEL IN RODENTS
JAGIEŁŁO-WÓJTOWICZ E.,1* KLEINROK Z.,1 SURMACZYŃSKA B.,1 BARAN E.,1 FELDO M.,1 NOWICKY J.W.2
1) Department of Pharmacology, Medical Academy, Jaczewskiego
8, 20-090 Lublin, Poland.
2) Ukrainian Anti-Cancer Institute, Margaretenstrasse 7, 1040 Vienna, Austria.
* Author to whom correspondence should be addressed.
Summary: The influence of Ukrain on the activity of aminotransferases (ALT and AST) and on the serum total protein content was estimated in mice and rats of both sexes receiving single or repeated doses of the drug. It was found that one hour after intraperitoneal (i.p.) administration of Ukrain no characteristic changes were recorded in the activity of the investigated enzymes, or in the serum protein content of animals of either sex. Similar effects were observed after three months treatment with Ukrain in rats of either sex. Only in mice receiving Ukrain for three months was a rise in ALT and AST activity found. No particular changes were observed in the total serum protein level, except for a small decrease in the sera of male mice.